Senior Liver cell scientist

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King's College Hospital NHS Foundation Trust is one of the UK's largest and busiest teaching Trusts with a turnover of c£1.8 billion, 1.5 million patient contacts a year and more than 15,000 staff based across 5 main sites in South East London. The Trust provides a full range of local hospital services across its different sites, and specialist services from King's College Hospital (KCH) sites at Denmark Hill in Camberwell and at the Princess Royal University Hospital (PRUH) site in the London Borough of Bromley.

Job overview

We currently have an exciting opportunity for a Band 7 researcher to join our Hepatocyte Biology and Transplantation Group at the Mowat Labs at King's College Hospital. Housed within the Institute of Liver Studies, MowatLabs, brings together a critical mass of clinicians, researchers, nurses, intensivists, surgeons and transplant specialists, in a collaborative research environment, strengthening the quality and output of research predominately for children's liver disease, but also for research into children's respiratory medicine, gastroenterology, and sickle cell disease.

Main duties of the job

The role of this new position of Senior Liver Cell Scientist will be to develop basic and translational research on 1) new advanced therapy medicinal products (ATMPs) for paediatric liver disease using 3D bioprinting technology and 2) new extracellular matrix biomaterials for 3D bioprinting applications.

The post holder will also participate in the GMP production of primary human hepatocytes in the Cell Therapy Unit, after appropriate training.

Working for our organisation

King's College Hospital NHS Foundation Trust is one of the UK's largest and busiest teaching Trusts with a turnover of c£1 billion, 1.5 million patient contacts a year and more than 15,000 staff based across South East London. The Trust provides a full range of local and specialist services across its five sites. The trust-wide strategy of Strong Roots, Global Reach is our Vision to be BOLD, Brilliant people, Outstanding care, Leaders in Research, Innovation and Education, Diversity, Equality and Inclusion at the heart of everything we do. By being person-centred, digitally-enabled, and focused on sustainability, we aim to take Team King's to another level.

We are at a pivotal point in our history and we require individuals who are ready to join a highly professional team and make a real, lasting difference to our patients and our people.

King's is committed to delivering Sustainable Healthcare for All via our Green Plan. In line with national Greener NHS ambitions, we have set net zero carbon targets of 2040 for our NHS Carbon Footprint and 2045 for our NHS Carbon Footprint Plus. Everyone's contribution is required in order to meet the goals set out in our Green Plan and we encourage all staff to work responsibly, minimising their contributions to the Trust's carbon emissions, waste and pollution wherever possible.

Detailed job description and main responsibilities

The post holder is a member of a multidisciplinary team developing the use of hepatocyte transplantation, and related cell-based therapies, in children with liver disease. They will be based at two locations the Institute of Liver Studies laboratories and the Cell Isolation Unit.

The post is split between research (80-90%) and GMP cell isolation work (10-20%).

The post holder is responsible for the development of new extracellular matrix-based biomaterials for 3D bioprinting applications and will be working within the 3D bioprinting team which is investigating new advanced therapy medicinal products (ATMPs) for paediatric liver disease using 3D bioprinting technology. They also perform cell isolations aiming to produce high quality cells for clinical administration.

The post holder should have a PhD in Biomedical Engineering/Cell Biology or equivalent experience with tissue engineering or relevant area of engineering and / or scientific research. Experience working with biomaterials and/or ECM proteins is desirable.

The post holder will conduct independent research into ECM-based bioinks for liver tissue engineering applications; collaborate closely with another senior researcher and a PhD student as part of the bioprinting sub-group within the lab; present their work in weekly research meeting; provide support and advice to students within the group; develop figures, search scientific literature, assist in writing manuscripts, submit abstracts, and present data at local and international meetings; participate in the isolation of liver cells under good manufacturing practices (GMP); Attend educational sessions, such as relevant lectures and journal clubs.

Person specification

qualification

Essential criteria

• Relevant PhD in appropriate Biomedical Engineering/Life Sciences subject OR equivalent experience Knowledge and Exp

Desirable criteria

• Experience of working in a GMP (Good Manufacture Practice) lab environment or in a 'clean room' environment

IMPORTANT

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• To enquire about your application or inform us of any changes in your circumstances, please contact the named person on this advert
• Please provide email addresses for referees where possible
• Click here to see the range of benefits we offer
• Please review the documentation on our recruitment microsite, particularly the Trust's criminal records checking policy
• All staff have a responsibility for safeguarding children and vulnerable adults and for ensuring they are aware of the specific duties relating to their role.
• Please note that the closing date is given as a guide. On occasion, we might close a vacancy early due to a high number of applications being received. You are advised to submit your application as early as possible to avoid disappointment.

King's College Hospital NHS Foundation Trust Annual Reports and Other Corporate Publications

King's Health Partners Academic Health Science Centre Website

King's College Hospital is part of King's Health Partners Academic Health Sciences Centre (AHSC), a pioneering collaboration between King's College London, and Guy's and St Thomas', King's College Hospital and South London and Maudsley NHS Foundation Trusts.

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Documents to download

• Senior Liver cell scientist (PDF, 408.4KB)
• Denmark Hill Site Map (PDF, 1.2MB)
• Princess Royal (PRUH) Site map (PDF, 1.4MB)
• Visa and Sponsorship Information (PDF, 352.6KB)