Senior Scientist Mass Spectrometry (Proteomics)

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About Oxford BioTherapeutics:

Oxford BioTherapeutics is a clinical-stage biotechnology company focusing on the development of antibody therapeutics for the treatment of cancer. OBT's OGAP-verify® platform is the world's largest, cancer specific, membrane protein library, directly measuring plasma membrane protein expression in patient tumours. OGAP is used to identify novel, highly tumour specific antigens for novel first-in-class ADC, T-cell Engager (TCE) and Chimeric Antigen Receptor (CAR-T) targets. Our lead asset, OBT076, is an Antibody Drug Conjugate (ADC) in Phase 1b clinical development. Our clinical and pre-clinical pipeline of novel biologics is balanced between internal programs, focused on ADCs and checkpoint regulators, and externally partnered programs with key innovators in oncology such as Roche, GSK and Zymeworks.

Purpose of the Role

The role will lead the mass spectrometry proteomics laboratory work at OBT's Oxford research facility. The role will generate quantitative proteomics data from human tissues in support of OBT's OGAP verify, oncology target discovery platform, with the aim of identifying novel oncology drug targets for development with antibody-based drug therapies (ADCs, TCEs, CAR-T, Radiopharmaceuticals)

Roles and Responsibilities:

• Maintain, optimise and operate Thermo Exploris nano-LC mass spectrometers

• Train staff in mass spectrometry and proteomics

• Conduct routine data generation on human oncology samples

• Work with bioinformatics research function to analyse data

• Work with the wet lab to support human tissue analysis

• Work with line manager to generate data in support of existing collaborations and new business development opportunities.

• Perform method development work as required. (This is only a minor requirement of the role)

Please note the roles and responsibilities for the position include but are not limited to the above.

Knowledge, Experience, and Skills:

Essential:

• PhD in proteomics, mass spectrometry, protein biochemistry or bio/analytical chemistry

• Located/ability to relocate to Oxford/Oxfordshire area

• Knowledge of running a mass spectrometry laboratory through post-doctoral work in either CRO, commercial, service or academic lab experience

• Knowledge of operating, maintaining and troubleshooting Thermo mass spectrometers and associated software and nano-HPLC systems

• Ability to accurately record data in Electronic Lab Notebook systems

• Knowledge of quantitative proteomics methods

• Line management experience

• Ability to deliver critical data to tight deadlines

• Highly organised and methodical

• Ability to train and inspire others

• Ability to synthesise and communicate findings within the internal team (with possible external presentations)

Desirable:

• 3+ years post-doctoral experience

• Experience in a commercial and time critical environment

• Knowledge or proteomics bioinformatics approaches and software

• Knowledge of protein biochemistry and chromatography methods

• Knowledge of oncology would be desirable, but not essential

• Knowledge of proteogenomic methods and NGS would be desirable

• Any knowledge of targeted quantitation methods would be useful

One of our top priorities is to maintain the health and wellbeing of our employees and their families. To achieve this goal, we offer comprehensive benefits.

Benefits Offered:

• Private health care (Bupa)

• Health Cash Plan

• Generous pension scheme with potential employer contribution of up to 10% (based on match contributions)

• Discretionary annual bonus scheme

• Free onsite parking

• Office snacks

• Enhanced holiday entitlement above statutory minimum plus public holidays

• Employee Referral Bonus Program

• Annual training budget for professional development

• New hire share options

• Team building events and activities

Equal Opportunities Statement

We are committed toequalityofopportunityfor all employee and applications from individuals are encouraged regardless of age, disability, sex, gender reassignment, sexual orientation, pregnancy and maternity, race, religion or belief and marriage and civil partnerships.

Why Join Us

We promote a culture of innovation, responsibility, and collective commitment to our goals. We believe that by bringing together our diverse skills and perspectives, we can develop novel, robust cures for one of today's most challenging health conditions.

Our people often describe OBT's culture as friendly, collaborative, and hard-working. We recognise that our team is only as strong as the individuals within it, which is why, in addition to hiring the best people, we strive to provide a working environment based on cooperation, creativity, and mutual respect.