Cryo Electron Microscopy Facility Manager
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About us
King's College London (KCL) is seeking a highly motivated cryo-electron microscopy (cryo-EM) expert to manage its newly established Cryo-EM Structural Discovery Facility.
The new high-resolution cryo-EM facility was established following KCL's acquisition of a 200 keV JEOL cryoARM200 cold-FEG autoloading electron microscope with an energy filter and the latest-generation Gatan K3 camera. The facility sits within the Research Platforms team, part of the Research Management and Innovation Directorate (RMID) and operates in close collaboration with the Centre for Ultrastructural Imaging (CUI), which provides additional cryo-EM sample preparation/vitrification, storage equipment and side-entry holder electron microscopes for sample screening. Whilst suitable of collecting data capable of producing
About the role
This is an exciting opportunity to contribute to cutting-edge structural biology research through single-particle cryo-electron microscopy and cryo-electron tomography, while playing a pivotal role in the operation and development of the facility.
The Facility Manager will be responsible for electron microscope operation and the management, support and future development of the facility, in a financially sustainable manner. The post holder will support multiple projects simultaneously and deliver high-quality training and technical assistance to a range of internal and external academic and industrial researchers, offering expert advice to meet their research objectives while optimising the facility's utilisation.
This is a senior role in cryo-EM, requiring a high level of technical expertise and strategic leadership within the field. The successful candidate will have in-depth knowledge and hands-on experience in single-particle cryo-EM, including sample preparation, instrument operation for sample screening and automate data acquisition, and image processing. In addition to their technical expertise, they will play a key role in driving the strategic development of the facility, optimising workflows, and implementing best practices to enhance efficiency and research output. Strong organisational and leadership skills are essential to ensure the facility operates effectively and continues to evolve in line with advancements in cryo-EM technology and align with the strategic goals of Research Platforms, RMID and King's.
This is a full-time post (35 Hours per week), and you will be offered an indefinite contract.
About you
To be successful in this role, we are looking for candidates to have the following skills and experience:
Essential criteria
1. PhD qualified in relevant subject area, or equivalent
2. Expertise in cryo- TEM operation, including screening and high-resolution data collection
3. An in-depth working knowledge of current methods and procedures for cryo-EM specimen preparation and imaging technology.
4. Experience in training new users and facilitating access to high-end instrumentation.
5. Experience with cryo-EM data collection software (most desirably SerialEM and/or Gatan Latitude).
6. Knowledge of some elements of facility management, for example - dealing with day-to-day operations in a similar facility, staff supervision, procurement or financial processes.
7. A good understanding of health and safety procedures and its implementation in the workplace.
8. Excellent communication skills, along with strong interpersonal skills, including ability to engage senior management and communicate with staff at all levels.
Desirable criteria
1. Experience with the maintenance and basic troubleshooting of Cryo- TEMs
2. A good understanding of cryo-EM data management, such as data transfer and storage, and network clustering.
3. Experience in and/or an understanding of FIB-milling and/or cryo-CLEM methodologies
4. Experience in facility pricing, budget management and reporting.
5. Proficiency using data processing software packages (CCPEM, CryoSPARC, Relion, IMOD, etc.)
Downloading a copy of our Job Description
Full details of the role and the skills, knowledge and experience required can be found in the Job Description document, provided at the bottom of the next page after you click "Apply Now". This document will provide information of what criteria will be assessed at each stage of the recruitment process.
Further Information
We pride ourselves on being inclusive and welcoming. We embrace diversity and want everyone to feel that they belong and are connected to others in our community.
We are committed to working with our staff and unions on these and other issues, to continue to support our people and to develop a diverse and inclusive culture at King's.
We ask all candidates to submit a copy of their CV, and a supporting statement, detailing how they meet the essential criteria listed in the advert. If we receive a strong field of candidates, we may use the desirable criteria to choose our final shortlist, so please include your evidence against these where possible.
To find out how our managers will review your application, please take a look at our ' How we Recruit ' pages.
Interviews are due to be held on 06th and 11th March
We are able to offer sponsorship for candidates who do not currently possess the right to work in the UK.